Levocetirizine Dihydrochloride

SKU: orb2901487

Description

Levocetirizine dihydrochloride ((R)-Cetirizine dihydrochloride) is a third-generation peripheral H1-receptor antagonist. Levocetirizine dihydrochloride is an antihistaminic agent which is the R-enantiomer of Cetirizine. Levocetirizine dihydrochloride has a higher affinity for the histamine H1-receptor than (S)-Cetirizine and can effectively treat allergic rhinitis and chronic idiopathic urticaria.

Images & Validation

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Key Properties

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CAS Number	130018-87-0
MW	461.81
Purity	>98% (HPLC)
Formula	C₂₁H₂₇Cl₃N₂O₃
SMILES	O=C(O)COCCN1CCN([C@@H](C2=CC=C(Cl)C=C2)C3=CC=CC=C3)CC1.Cl.Cl
Target	Histamine Receptor
Solubility	In Vitro: DMSO : 100 mg/mL (216.54 mM; Ultrasonic )H2O : 100 mg/mL (216.54 mM; Ultrasonic)

Bioactivity

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In Vivo

Levocetirizine (0.4 mg/kg; oral administration; male Sprague-Dawley rats) treatment shows that the Cmax, AUC0-t, AUC0-∞ and t1/2 are 0.34 μg/mL, 3.26 μg h/mL, 3.67 μg h/mL and 2.34 hours, respectively in Sprague-Dawley rats. Animal model: 30 male Sprague-Dawley rats (8 weeks old; 200-250 g). Dosage: 0.4 mg/kg. Administration: Oral administration (Pharmacokinetic Analysis). Result: The Cmax, AUC0-t, AUC0-∞ and t1/2 were 0.34 μg/mL, 3.26 μg h/mL, 3.67 μg h/mL and 2.34 hours, respectively.

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Gene Symbol

Histamine Receptor

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