Levomefolic Acid

SKU: orb1220506

Description

Levomefolinic acid is a natural active form of folic acid used at the cellular level for DNA reproduction the cysteine cycle and the regulation of homocysteine among other functions. Levomefolinic acid is used as a treatment and to prevent Folate Deficiency.(In Vitro):Levomefolic acid (5-MTHF) shows interaction with residues Glu406, Ile 418, Lys417 and Tyr453, of which Lys 417 and Tyr 453 play a strong physiological role in the interaction between S1 and ACE and may act as a potential inhibitor of the S1:ACE2 interaction of the SARS-CoV-2 virus.Levomefolic acid (5-MTHF) (50 nM, 72 h) increases intracellular folate metabolite activity by 7-fold better than folic acid by 2-fold in human lymphoblastoid cell line (LCL), and is a good folic acid supplement.

Images & Validation

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Key Properties

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CAS Number	31690-09-2
MW	459.46
Purity	>98% (HPLC)
Formula	C₂₀H₂₅N₇O₆
SMILES	CN1[C@@H](CNc2ccc(cc2)C(=O)N[C@@H](CCC(O)=O)C(O)=O)CNc2nc(N)[nH]c(=O)c12
Target	Endogenous Metabolite
Solubility	H2O:5 mg/mL (10.88 mM);DMSO:0.526 mg/mL (1.14 mM)

Bioactivity

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In Vitro

Levomefolic acid (5-MTHF) shows interaction with residues Glu406, Ile 418, Lys417 and Tyr453, of which Lys 417 and Tyr 453 play a strong physiological role in the interaction between S1 and ACE and may act as a potential inhibitor of the S1: ACE2 interaction of the SARS-CoV-2 virus. Levomefolic acid (5-MTHF) (50 nM, 72 h) increases intracellular folate metabolite activity by 7-fold better than folic acid by 2-fold in human lymphoblastoid cell line (LCL), and is a good folic acid supplement.

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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5-MTHF

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Endogenous Metabolite

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