Licoflavone B

SKU: orb1297302

Description

Licoflavone B is a schistosomicidal agent that potently inhibits S. mansoni ATPase and ADPase enzymes, with IC50 values of 23.78 μM and 31.50 μM, respectively. This compound is a useful research tool for studying schistosome metabolism and for in vitro investigations into novel anti-parasitic strategies.

Research Area

Infectious Disease & Virology, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	91433-17-9
MW	390.47
Purity	99.96% (May vary between batches)
Formula	C₂₅H₂₆O₄
SMILES	CC(C)=CCc1cc(ccc1O)-c1cc(=O)c2cc(CC=C(C)C)c(O)cc2o1
Target	ATPase,Anti-infection,Parasite
Solubility	DMSO:60 mg/mL (153.66 mM);10% DMSO+90% Corn Oil:2.5 mg/mL (6.4 mM)

Bioactivity

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Target IC50

S. mansoni ADPase:31.50 µM (IC50)|ATPase (S. mansoni):23.78 µM (IC50)

In Vitro

Phytochemical investigation revealed 12 constituents identified as (E)-1-[2,4-dihydroxy-3-(3-methyl-2-butenyl)phenyl]-3-(8-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)-2-propen-1-one (1), 3,4-dihydro-8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b']dipyran-3-ol (2), biochanin B (3), glabrol (4), glabrone (5), hispaglabridin B (6), Licoflavone B (7), licorice glycoside B (8), licorice glycoside E (9), liquiritigenin (10), liquiritin (11), and prunin (12). Eleven of these constituents showed significant influenza virus NA inhibition in a chemiluminescence (CL)-based assay. Additional tests, including (i) a cell-based cytopathic effect inhibition assay (general antiviral activity), (ii) the evaluation of cytotoxicity, (iii) the inhibition of the NA of Clostridium perfringens (CL- and fluorescence (FL)-based assay), and (iv) the determination of self-fluorescence and quenching, provided further perspective on their anti-influenza virus potential, revealing possible assay interference problems and false-positive results.

Storage & Handling

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Storage	keep away from direct sunlight \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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inhibit, Licoflavone B, Parasite, Inhibitor, Anti-infection, Antiinfection, Antifection, ATPase

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Compound Identifiers

PubChem CID

11349817 ↗

Key Properties

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No computed properties available.

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Licoflavone B (orb1297302)

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Purity:	>98% (HPLC)
CAS Number:	91433-17-9
MW:	390.47
Formula:	C₂₅H₂₆O₄

Licoflavone B

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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