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LIFR/GPBAR1 modulator 1

SKU: orb3173440

Description

LIFR/GPBAR1 modulator 1 is an orally active, potent GPBAR1 agonist (EC50= 0.2 μM) and LIFR inhibitor (IC50= 7.9 μM). It enhances the expression of leukemia inhibitory factor (LIF)-mediated LIFR and GPBAR1 mRNA, while significantly reducing the expression of fibrosis markers (COL1A1, ASMA, and TGFβ), decreasing TIMP1 levels, and increasing MMP9 expression. LIFR/GPBAR1 modulator 1 is applicable for research into human fibrotic diseases.

Research Area

Pharmacology & Drug Discovery, Protein Biochemistry, Stem Cell & Developmental Biology

Images & Validation

Key Properties

TargetMMP,TGF-beta/Smad,GPCR19

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information