Lipid 88

SKU: orb3033115

Description

Lipid88 is a high-performance, novel ionizable lipid component engineered for advanced mRNA-LNP vaccine delivery. LNP88 formulation demonstrates superior biodistribution, achieving >10-fold higher transfection efficiency in spleen and lymph nodes compared to benchmark lipids like ALC-0315 via intramuscular delivery. When encapsulating antigen-encoding mRNA (e.g., optimized mCSA construct), Lipid-88 based LNPs drive robust humoral and cellular immunity, enabling complete protection against challenging SARS-CoV-2 variants (WA1/2020, Omicron BA.1, BQ.1) in preclinical models. Its design prioritizes potent immunogenicity with favorable safety profiles.

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Key Properties

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CAS Number	2982842-99-7
MW	1459
Purity	>98%
Formula	C₇₉H₁₄₇N₃O₂₀
SMILES	CCCCCCC(CCCC)COC(OCCOC(CCN(CCC(OCCOC(OCC(CCCC)CCCCCC)=O)=O)CCCN(C)CCCN(CCC(OCCOC(OCC(CCCC)CCCCCC)=O)=O)CCC(OCCOC(OCC(CCCC)CCCCCC)=O)=O)=O)=O

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Disclaimer	For research use only

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Lipid 88 (orb3033115)

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Applications:	IF, IHC-Fr, IHC-P
Predicted Reactivity:	Canine, Equine, Gallus, Human, Mouse, Porcine
Reactivity:	Rat
Species/Host:	Rabbit
Clonality:	Polyclonal
Conjugation:	Unconjugated

Applications:	IF, IHC-Fr, IHC-P
Predicted Reactivity:	Canine, Human, Mouse
Reactivity:	Rat
Species/Host:	Rabbit
Clonality:	Polyclonal
Conjugation:	Unconjugated

Purity:	0.98
MW:	1395.05
Formula:	C₇₉H₁₄₇O₁₆N₃

Lipid 88

Description

Images & Validation

Key Properties

Storage & Handling

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Lipid 88 (orb3033115)

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