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Lisuride maleate

SKU: orb1685355

Description

Lisuride maleate is a non-selective dopamine agonist and G-protein-biased 5-HT2A receptor agonist that inhibits prolactin secretion. It is utilized in research models of Parkinson's disease, depression, and hyperprolactinemia for both in vitro receptor studies and in vivo behavioral and neuroendocrine experiments.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number19875-60-6
MW454.52
Purity99.85% (May vary between batches)
FormulaC24H30N4O5
SMILESC(=C\C(O)=O)\C(O)=O.CN1[C@]2(C(C=3C=4C(C2)=CNC4C=CC3)=C[C@H](NC(N(CC)CC)=O)C1)[H]
TargetDopamine Receptor,5-HT Receptor
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.2 mM);H2O:5 mM;Ethanol:5 mM;DMSO:20 mg/mL (44 mM)

Bioactivity

In Vivo
Lisuride maleate, at doses of 0.78 mg/kg (intraperitoneal injection) and 3.13 mg/kg (oral administration), exhibits a potency that is 3-4 times higher when administered intraperitoneally compared to oral administration . When administered intraperitoneally (ip) at doses ranging from 0.78 to 3.13 mg/kg, Lisuride maleate effectively antagonizes the motor inhibition and hypothermia induced by reserpine . The effects of Lisuride maleate (0.78-3.13 mg/kg, intraperitoneal injection) are similar to those of apomorphine and D-amphetamine, and it can induce significant hypothermia at doses as low as 0.10 mg/kg .

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Lisuride Maleate
Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

Protocol Information

Available Sizes

Select a size below

1 mg
$ 240.00
5 mg
$ 660.00
1 ml x 10 mM (in DMSO)
$ 660.00
10 mg
$ 930.00
25 mg
$ 1,370.00
50 mg
$ 1,820.00
100 mg
$ 2,470.00
DispatchUsually dispatched within 5-10 working days
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