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LMDP10

SKU: orb3173085

Description

LMDP10 is an orally active 3-aminoquinazoline derivative that activates the Keap1-Nrf2 pathway. It binds to Keap1, inhibiting the Keap1-Nrf2 interaction and subsequently activating the Nrf2 pathway. This leads to increased levels of Nrf2, SOD, and GSH, while reducing MDA and TNF-α levels. As a result, LMDP10 alleviates neurodegeneration and improves memory in Alzheimer's disease (AD) rat models. LMDP10 is applicable for Alzheimer's disease (AD) research.

Images & Validation

Key Properties

CAS Number2760446-25-9
MW492.51
FormulaC29H21FN4O3
SMILESO=C(NN1C(=O)C=2C=CC=CC2N=C1CN(C3=CC=C(F)C=C3)C(=O)C=4C=CC=CC4)C=5C=CC=CC5
TargetNrf2

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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LMDP10 (orb3173085)

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