Loxapine succinate

SKU: orb1308691

Description

Loxapine succinate

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	27833-64-3
MW	445.9
Purity	99.92%
Formula	C₂₂H₂₄ClN₃O₅
SMILES	OC(=O)CCC(=O)O.CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2
Target	5-HT Receptor,Dopamine Receptor
Solubility	Ethanol:2 mg/mL (4.49 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.4 mM);DMSO:82 mg/mL (183.9 mM)

Bioactivity

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Target IC50	D2 receptor (human):24 nM(Ki)\|5-HT2 (human):6.2 nM(Ki)\|D4 receptor (human):7.5 nM(Ki)\|5-HT2 (bovine):6.6 nM(Ki)\|5-HT2 (bovine):6.8 nM(Ki)
In Vivo	Loxapine effectively facilitates the binding of [3H]ketanserin to 5-HT2 receptors in both the human frontal cortex (ki=6.2 nM) and the bovine frontal cortex (ki=6.6 nM). Additionally, in LPS-activated mixed glial cells, loxapine at concentrations of 0.2 μM, 2 μM, and 20 μM, successfully reduces the secretion of IL-1β and IL-2. Read more...
In Vitro	In rats, subcutaneous injection of Loxapine (0.3 mg/kg) induces general stiffness. In the rat brain, administering Loxapine (5 mg/kg) does not alter dopamine receptor density, but it reduces serotonin receptor density. Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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5HT Receptor, 5HTReceptor, 5-HT Receptor, 5-HT2 (bovine), 5-HT2 (human), antipsychotics, Dopamine Receptor, DopamineReceptor, Daxolin, D4, D2, Cloxazepin, IL-2, Loxapine succinate salt, Loxapac, Loxapine

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Compound Identifiers

PubChem CID

71399 ↗

Key Properties

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No computed properties available.

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