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LOXO-195

SKU: orb1298066

Description

(6RS)-LOXO-195 (BAY 2731954) is a highly potent and selective inhibitor of the Trk family of tyrosine kinases. It is utilized in biochemical and cellular research to investigate Trk-driven oncogenesis and has demonstrated antitumor activity in preclinical in vivo models of NTRK-rearranged cancers.

Research Area

Signal Transduction

Images & Validation

Key Properties

CAS Number1350884-56-8
MW380.42
Purity99.54% (May vary between batches)
FormulaC20H21FN6O
SMILESFC=1C=C2[C@@]3(N(C4=NC=5N(C=C4)N=CC5C(=O)NC(C)CCC2=NC1)CCC3)[H]
TargetTrk receptor
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.26 mM);DMSO:50 mg/mL (131.43 mM)

Bioactivity

Target IC50
TrkA:0.6 nM|TrkC:<2.5 nM

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Trk, Trk receptor, Trkreceptor, (6RS)-LOXO 195, (6RS)-LOXO195, (6RS)-LOXO-195, BAY 2731954, BAY2731954, BAY-2731954, LOXO 195, LOXO195, LOXO-195

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Key Properties

No computed properties available.

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Protocol Information

LOXO-195 (orb1298066)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

2 mg
$ 70.00
5 mg
$ 90.00
1 ml x 10 mM (in DMSO)
$ 100.00
10 mg
$ 120.00
25 mg
$ 190.00