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Loxoribine

SKU: orb1219584

Description

Loxoribine is a guanosine analog. Loxoribine is an orally bioavailable and selective Toll-like receptor (TLR) 7 agonist. It has anti-viral and anti-tumor activities.Loxoribine is a potent new immunostimulant with a relatively broad spectrum of immunobiological activities.loxoribine activates cells of the innate immune system selectively via the Toll-like receptor (TLR) 7/MyD88-dependent signaling pathway. Loxoribine causes maturation of human monocyte-derived dendritic cells DCs and stimulates their Th-1- and Th-17-polarizing capability. Loxoribine (250 μM; 48 hours) stimulates maturation of MoDCs as shown by up-regulation of CD80, CD83, CD40, CD54, and CCR7. In vivo, Loxoribine (2 mg; s.c.or i.v.) activates murine natural killer (NK) cells.

Images & Validation

Key Properties

CAS Number121288-39-9
MW339.3
Purity>98% (HPLC)
FormulaC13H17N5O6
SMILESNc1nc2n([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c(=O)n(CC=C)c2c(=O)[nH]1
TargetTLR
SolubilityIn Vitro: DMSO : 100 mg/mL (294.72 mM)

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

7-Allyl-8-oxoguanosine,RWJ 21757

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Loxoribine (orb1219584)

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200 mg
500 mg
2 mg
$ 110.00
5 mg
$ 160.00
10 mg
$ 250.00
25 mg
$ 400.00
50 mg
$ 580.00
100 mg
$ 830.00