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LTβR-IN-1

SKU: orb1709239

Description

LTβR-IN-1 is a selective lymphotoxin beta receptor (LTβR) inhibitor that blocks p52 nuclear translocation induced by ligands like TWEAK with an IC50 of 10 µM, without affecting TNF-α-mediated p65 translocation. This tool compound is used in vitro to study the non-canonical NF-κB pathway in immune regulation and lymphoid organogenesis.

Research Area

Immunology & Inflammation, Signal Transduction

Images & Validation

Key Properties

CAS Number2189366-77-4
MW320.35
Purity99.09%
FormulaC18H16N4O2
SMILESC[C@@H](N1Cc2ccccc2C1=O)C(=O)Nc1nc2ccccc2[nH]1
TargetLTR,NF-κB
SolubilityDMSO:113 mg/mL (352.74 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (12.49 mM)

Bioactivity

Target IC50
LTβR (p52 translocation):10 μM |LTβR (p52 translocation):0.169 μM

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

LTbR-IN-1, LTbetaR-IN-1, LTR, LTβR IN 1, LTβR,p52 translocation, LTβRIN1, LTβR-IN-1, NF-κB, NFκB, NF-kB, NFkB
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Key Properties

No computed properties available.

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LTβR-IN-1 (orb1709239)

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% DMSO +
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% Tween 80 +
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Available Sizes

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1 mg
$ 70.00
1 ml x 10 mM (in DMSO)
$ 120.00
5 mg
$ 120.00
10 mg
$ 160.00
25 mg
$ 280.00
50 mg
$ 390.00
100 mg
$ 540.00
500 mg
$ 1,030.00
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