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Lusianthridin

SKU: orb1297297

Description

Lusianthridin, a natural compound isolated from Dendrobium venustum, inhibits cell migration at non-cytotoxic concentrations. Its mechanism involves suppressing Src-STAT3 signaling, which promotes the degradation of the oncoprotein c-Myc, making it a candidate for research in cancer metastasis and cell signaling pathways.

Research Area

Cell Biology

Images & Validation

Key Properties

CAS Number87530-30-1
MW242.27
Purity99.11% (May vary between batches)
FormulaC15H14O3
SMILESOC1=C2C=3C(CCC2=CC(OC)=C1)=CC(O)=CC3
Targetc-Myc

Bioactivity

In Vitro
Lusianthridin showed appreciable cytotoxicity against human lung cancer cell lines with IC50 values of 65.0 μg/mL. Lusianthridin (0-100 μM) inhibited cell viability at concentrations greater than 50 μM in both H460 and H292 cells. Lusianthridin significantly reduced the CSC populations in both H460 and H292 cells of the CSC spheres, with a significant decrease in the size of the H460 CSC spheres by approximately 10%, 63%, and 77% at day 3 at concentrations of 5, 10, and 20 μM, respectively.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Inhibitor, Lusianthridin, Myc, inhibit, c-Myc, cMyc
Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

Lusianthridin (orb1297297)

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Available Sizes

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1 mg
$ 260.00
5 mg
$ 580.00
1 ml x 10 mM (in DMSO)
$ 590.00
10 mg
$ 820.00
25 mg
$ 1,220.00
50 mg
$ 1,660.00
DispatchUsually dispatched within 3-5 working days
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