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LUT014

SKU: orb1308108

Description

LUT014 is a potent B-Raf inhibitor (IC50: 11.7 nM) developed to mitigate EGFR inhibitor-induced acneiform lesions. It is a research tool for studying targeted therapy combinations and resistance mechanisms in oncology, applicable in both in vitro and in vivo models of skin toxicity and cancer.

Research Area

Signal Transduction

Images & Validation

Key Properties

CAS Number2274819-46-2
MW528.49
Purity99.03%
FormulaC27H19F3N8O
SMILESCc1ccc2c(Nc3cccc(OC(F)(F)F)c3)nccc2c1Nc1ncccc1-c1ncnc2[nH]cnc12
TargetRaf
SolubilityDMSO:50 mg/mL (94.61 mM);H2O:< 0.1 mg/mL (insoluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.78 mM)

Bioactivity

Target IC50
B-Raf:11.7 nM

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
DisclaimerFor research use only

Alternative Names

Inhibitor, LUT 014, LUT014, LUT-014, inhibit, B-Raf, Raf kinases, Raf

Similar Products

  • LUT014 [orb1218382]

    >98% (HPLC)

    2274819-46-2

    528.5

    C27H19F3N8O

    1 g, 500 mg, 200 mg, 2 mg, 5 mg, 100 mg, 25 mg, 10 mg, 50 mg
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Key Properties

No computed properties available.

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LUT014 (orb1308108)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 100.00
5 mg
$ 190.00
1 ml x 10 mM (in DMSO)
$ 210.00
10 mg
$ 240.00
25 mg
$ 410.00
50 mg
$ 560.00
100 mg
$ 760.00
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