Luteolin 5-O-glucoside

SKU: orb1684438

Description

Luteolin 5-O-glucoside is a natural flavonoid that suppresses LPS-induced nitric oxide (NO) and t-BHP-induced reactive oxygen species (ROS) in RAW 264.7 cells, while also inhibiting iNOS and COX-2 expression in macrophages. This compound is widely used in research on inflammation, oxidative stress, and related signaling pathways in both cellular and animal models.

Research Area

Immunology & Inflammation, Metabolism Research, Neuroscience, Signal Transduction

Images & Validation

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Key Properties

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CAS Number	20344-46-1
MW	448.38
Formula	C₂₁H₂₀O₁₁
SMILES	O(C1=C2C(OC(=CC2=O)C3=CC(O)=C(O)C=C3)=CC(O)=C1)[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O
Target	NOD,ROS,NOS,NO Synthase,Reactive Oxygen Species,COX

Bioactivity

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Target IC50

NO:64.36 μM|ROS:2.17 μM

In Vitro

In RAW 264.7 murine macrophages, luteolin 5-O-glucoside showed no significant cytotoxicity at concentrations up to 200 μM. Luteolin 5-O-glucoside inhibited LPS-induced NO production with an IC₅₀ of 64.36 μM, suppressed t-BHP-induced ROS generation (IC₅₀ = 2.17 μM), and dose-dependently downregulated iNOS and COX-2 expression, indicating notable anti-inflammatory and antioxidant activity.

Storage & Handling

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Storage	keep away from direct sunlight \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Luteollin 5-glucoside, Luteolin 5-O-glucoside, Luteolin 5 O glucoside, Luteolin 5Oglucoside

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Compound Identifiers

PubChem CID

5317471 ↗

Key Properties

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No computed properties available.

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