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Luteolin 5-O-glucoside

SKU: orb1684438

Description

Luteolin 5-O-glucoside is a natural flavonoid that suppresses LPS-induced nitric oxide (NO) and t-BHP-induced reactive oxygen species (ROS) in RAW 264.7 cells, while also inhibiting iNOS and COX-2 expression in macrophages. This compound is widely used in research on inflammation, oxidative stress, and related signaling pathways in both cellular and animal models.

Research Area

Immunology & Inflammation, Metabolism Research, Neuroscience, Signal Transduction

Images & Validation

Key Properties

CAS Number20344-46-1
MW448.38
FormulaC21H20O11
SMILESO(C1=C2C(OC(=CC2=O)C3=CC(O)=C(O)C=C3)=CC(O)=C1)[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O
TargetROS,NO Synthase,Reactive Oxygen Species,NOD,COX,NOS

Bioactivity

Target IC50
NO:64.36 μM|ROS:2.17 μM
In Vitro
In RAW 264.7 murine macrophages, luteolin 5-O-glucoside showed no significant cytotoxicity at concentrations up to 200 μM. Luteolin 5-O-glucoside inhibited LPS-induced NO production with an IC₅₀ of 64.36 μM, suppressed t-BHP-induced ROS generation (IC₅₀ = 2.17 μM), and dose-dependently downregulated iNOS and COX-2 expression, indicating notable anti-inflammatory and antioxidant activity.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Luteollin 5-glucoside, Luteolin 5-O-glucoside, Luteolin 5 O glucoside, Luteolin 5Oglucoside
Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

Protocol Information

Available Sizes

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5 mg
$ 740.00
DispatchUsually dispatched within 5-10 working days
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