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Lycorine

SKU: orb1222220

Description

Lycorine is a novel inhibitor of the growth and metastasis of hormone-refractory prostate cancer. It is a natural alkaloid extracted from the Amaryllidaceae plant family.

Images & Validation

Key Properties

CAS Number476-28-8
MW287.31
Purity>98% (HPLC)
FormulaC16H17NO4
SMILESC1CN2Cc3cc4c(cc3[C@H]3[C@H]2C1=C[C@@H]([C@H]3O)O)OCO4
TargetATPase
SolubilityIn Vitro: DMSO : 25 mg/mL (87.01 mM)

Bioactivity

In Vivo
Animal model: High-fat diet (HFD)-fed C57BL/6J mice. Dosage: 15 mg/kg, 30 mg/kg. Administration: Oral chow; once daily. Result: Ameliorated high-fat diet-induced hyperlipidemia, hepatic steatosis, and insulin resistance in mice.
In Vitro
Cell Viability Assay Cell line: HL-7702/SRE-Luc cells. Concentration: 16 hours. Incubation time: 5 μM; 10 μM; 20 μM; 40 μM. Result: Had no cytotoxicity on HL-7702 cells. Western blot analysis. Cell line: HL-7702/SRE-Luc cells. Concentration: 2 hours, 4 hours, 8 hours, 12 hours, 16 hours. Incubation time: 10 μM; 20 μM. Result: Decreased p-SREBF1, m-SREBF1, p-SREBF2 and p-SREBF1 protein expression. RT-PCR Cell line: C8161 cells. Concentration: 0 μM, 1.56 μM, 3.13 μM, 6.25 μM, 12.5 μM, 25 μM Incubation time: 48 hours. Result: Markedly suppressed the expression of VE-cadherin in a dose-dependent manner and also slightly diminished the expression of Sema4D in C8161 cells.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Lycorine | Galanthidine | NSC-401360 | NSC401360

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Lycorine (orb1222220)

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200 mg
500 mg
10 mg
$ 70.00
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$ 90.00
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100 mg
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