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Magnocurarine

SKU: orb1297293

Description

Magnocurarine is a bioactive alkaloid isolated from Magnolia officinalis. It serves as a research tool in pharmacological studies, with in vitro investigations exploring its potential neuromuscular blocking and autonomic ganglion-blocking activities.

Images & Validation

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Magnocurarine

Key Properties

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CAS Number6801-40-7
MW314.4
Purity>99.99% (May vary between batches)
FormulaC19H24NO3
SMILESC([C@@H]1C=2C(=CC(OC)=C(O)C2)CC[N+]1(C)C)C3=CC=C(O)C=C3
TargetOthers
SolubilityDMSO:55 mg/mL (174.94 mM)

Bioactivity

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In Vitro
The stem of Magnoliae officinalis (MO) cortex is always preliminarily processed before being applied in traditional Chinese medicine. The definite bioavailability of honokiol (HO) and magnolol (MA) in processed MO (PMO) and the effect of chemical profiling change on the pharmacokinetics of HO and MA are always a greater challenge compared with those of MO. Compared with that of MO, the pharmacokinetic profiling of HO and MA in the PMO was significantly changed and the mean Tmax of HO and MA was increased by 31 and 50% (P < 0.05), respectively; the mean AUC0-t and Cmax of HO were increased by 36 and 24% (P < 0.05), respectively. Subsequently, the chemical profiling of MO and PMO was investigated by a simple and rapid LC-Q/TOF-MS coupled with multivariate analysis method. Principal component analysis and hierarchical cluster analysis of the chromatographic data demonstrated that the chemical profiling of PMO was significantly different from that of MO. Eight marker components including six alkaloids (Magnocurarine, magnoflorine, roemerine and three unidentified peaks) and two lignans (obovatol and MA) were screened out by partial least-squares discriminant analysis.

Storage & Handling

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Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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Natural, inhibit, isolated, Inhibitor, Magnocurarine, compound

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Compound Identifiers

PubChem CID
53266 ↗

Key Properties

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No computed properties available.

Protocol Information

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Available Sizes

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1 mg
$ 300.00
5 mg
$ 670.00
1 ml x 10 mM (in DMSO)
$ 700.00
10 mg
$ 930.00
25 mg
$ 1,370.00
50 mg
$ 1,830.00
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