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Malabaricone B

SKU: orb1217788

Description

Malabaricone B is a Spice-derived phenolic, it induces mitochondrial damage in lung cancer cells via a p53-independent pathway.

Images & Validation

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Malabaricone B

Key Properties

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CAS Number63335-24-0
MW342.43
Purity>98% (HPLC)
FormulaC21H26O4
SMILESOc1ccc(CCCCCCCCC(c(c(O)ccc2)c2O)=O)cc1
TargetOthers
SolubilityIn Vitro: DMSO : 100 mg/mL (292.03 mM)

Bioactivity

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In Vivo
Malabaricone B (100 mg/kg; p. o; alternate day, 23 days) inhibits lung tumor (xenograft) growth in SCID mice.
In Vitro
Malabaricone B shows selective toxicity to human lung cancer (A549), malignant melanoma (A375) and T cell leukemia (Jurkat) cell lines, without showing toxicity to human normal intestinal (INT407), human kidney (HEK293) and lung fibroblast (WI-38) cells. Among the chosen cancer cell lines, Malabaricone B shows maximum cytotoxicity to the A549 cells (IC50 = 8.1 μM), which is significantly better than that of curcumin (IC50 = 26.7 μM). The Malabaricone B-induced apoptosis is mediated by an increase in the intracellular reactive oxygen species (ROS). Malabaricone B (2.5, 5, 10 and 20 μM) increases the BAX level while simultaneously decreasing the BCL-2 and BCL-XL levels in the A549 cells, triggering the mitochondrial apoptotic pathway as revealed from the release of cytochrome c, and the activation of caspase-9 and caspase-3.Malabaricone B exhibits a good level of antimicrobial activity when tested against avariety of microorganisms, including Staphylococcus aureus and Candida albicans.

Storage & Handling

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StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Similar Products

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  • Malabaricone B

    Malabaricone B [orb1296980]

    99.91% (May vary between batches)

    63335-24-0

    342.43

    C21H26O4

    1 mg, 5 mg, 10 mg, 25 mg, 50 mg, 1 ml x 10 mM (in DMSO), 2 mg
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5 mg
$ 480.00
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$ 710.00
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$ 1,620.00
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