Cart summary

You have no items in your shopping cart.

MeTC7

SKU: orb1739329

Description

MeTC7 is a small molecule antagonist of the vitamin D receptor (VDR) that demonstrates antitumor properties by suppressing PD-L1. It has shown efficacy in inhibiting tumor growth in both xenograft and transgenic mouse models, making it a valuable tool for cancer immunotherapy and oncology research.

Research Area

Metabolism Research

Images & Validation

Key Properties

CAS Number1817841-22-7
MW618.65
Purity99.69% (May vary between batches)
FormulaC32H48BrN3O4
SMILESO=C1N2C34[C@@]([C@]5(C)C(N2C(=O)N1C)(C=C3)C[C@@H](OC(CBr)=O)CC5)(CC[C@@]6(C)[C@]4(CC[C@@]6([C@@H](CCCC(C)C)C)[H])[H])[H]
TargetVitamin
SolubilityDMSO:20 mg/mL (32.33 mM);10% DMSO+90% Corn Oil:1 mg/mL (1.62 mM)

Bioactivity

Target IC50
VDR:2.9 μM
In Vivo
By intraperitoneal injection of 10 mg/kg MeTC7 was able to inhibit the growth of spontaneous transgenic TH-MYCN neuroblastoma and xenograft tumors in vivo.
In Vitro
MeTC7 disrupts the VDR-Ligand-binding domain in Silico. MeTC7 shows potent VDR inhibition activity with an IC50=2.9 μM. Treatment with 250 nM MeTC7 for 18 h was able to inhibit the expression of RXRα and Importin-4 and induce PARP1 cleavage, thereby inhibiting the viability of ovarian cancer cells.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

MeTC 7, MeTC7, Miransertib dimesylate, Miransertib mesylate, VD
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Key Properties

No computed properties available.

Documents Download

Datasheet
Product Information
Download

Request a Document

Protocol Information

MeTC7 (orb1739329)

  • Star
  • Star
  • Star
  • Star
  • Star
  • 0.0
Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

Login to Submit a Review

No reviews yet

Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

(This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 90.00
5 mg
$ 160.00
1 ml x 10 mM (in DMSO)
$ 200.00
10 mg
$ 260.00
25 mg
$ 470.00
50 mg
$ 680.00
100 mg
$ 960.00
DispatchUsually dispatched within 6-8 weeks
Bulk Enquiry