Methylthiouracil

SKU: orb1310741

Description

Methylthiouracil is a thiourea-based antithyroid compound that suppresses thyroid hormone synthesis. It is widely used in research to model hyperthyroidism and hyperlipidemia, and its anti-inflammatory properties, including inhibition of TNF-α, IL-6, NF-κB, and ERK1/2, make it applicable for studying related inflammatory pathways in vitro and in vivo.

Research Area

Cell Biology, Immunology & Inflammation, Signal Transduction

Images & Validation

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Key Properties

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CAS Number	56-04-2
MW	142.18
Purity	>99.99% (May vary between batches)
Formula	C₅H₆N₂OS
SMILES	CC1=CC(=O)NC(=S)N1
Target	NF-κB,Interleukin,Antiviral,TNF,ERK
Solubility	DMSO:27 mg/mL (189.9 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (14.07 mM)

Bioactivity

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In Vitro	Methylthiouracil acts to decrease the formation of stored thyroid hormone, as thyroglobulin in the thyroid gland. Methylthiouracil is also used in combination with radioactive iodine. Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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antithyroid, Inhibitor, Interleukin Related, Interleukin, ERK, Extracellular signal regulated kinases, Methylthiouracil, NFkB, NF-kB, NFκB, NF-κB, NSC9378, NSC-9378, Nuclear factor-κB, Nuclear factor-kappaB, inhibit, MTU, NSC 9378, NSC 193526, NSC193526, NSC-193526, Tumor Necrosis Factor Receptor, TNFR, TNF Receptor

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Compound Identifiers

PubChem CID

667493 ↗

Key Properties

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No computed properties available.

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