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MF-766

SKU: orb1297974

Description

MF-766

Research Area

Immunology & Inflammation, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number1050656-06-8
MW478.46
Purity98.06%
FormulaC27H21F3N2O3
SMILESOC(=O)c1ccc(cc1)C1(CC1)NC(=O)c1cccc2ccn(Cc3ccc(cc3)C(F)(F)F)c12
TargetProstaglandin Receptor
SolubilityDMSO:60 mg/mL (125.4 mM);10% DMSO+90% Corn Oil:2.5 mg/mL (5.23 mM)

Bioactivity

Target IC50
EP4:0. 23 nM (Ki)
In Vivo
MF-766 (oral gavage; 30 mg/kg; once daily; 21 days) exhibits TGI% of 49% in CT26 tumor model. But it does not exhibits significant difference in EMT6 and 4T1 tumor mode. MF-766 (oral gavage; 30 mg/kg combination with anti-PD-1 mDX400; once daily; 21 days; q4dx8) shows potent anti-tumor activities in different preclinical models the % of TGI are 89%, 66% and 40%, respectively in CT26 tumor, EMT6 and 4T1 tumor mode.
In Vitro
MF-766, at concentration ranging from 0.01 to 10 μM and pretreated for 1 hour before being stimulated with 50 ng mL IL-2—both with and without 0.33 μM PGE2 for 18 hours—effectively reverse the suppression of IFN-γ secretion in human NK cells caused by PGE2. Importantly the viability of NK cells remains unaffected by MF-76.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
DisclaimerFor research use only

Alternative Names

inhibit, inflammation disease, MF 766, MF766, MF-766, EP4, Inhibitor, cancer, arthritis, anti-tumor, AIA, Prostaglandin Receptor, ProstaglandinReceptor

Similar Products

  • MF-766 [orb1146624]

    >98%

    1050656-06-8

    478.471

    C27H21F3N2O3

    5 mg
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Key Properties

No computed properties available.

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MF-766 (orb1297974)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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1 mg
$ 120.00
5 mg
$ 220.00
1 ml x 10 mM (in DMSO)
$ 240.00
10 mg
$ 330.00
25 mg
$ 620.00
50 mg
$ 870.00
100 mg
$ 1,170.00
500 mg
$ 2,320.00
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