Cart summary

You have no items in your shopping cart.

MG-T-19

SKU: orb2802249

Description

MG-T-19 is a potent small molecule TIM-3 inhibitor (K_D=0.26 µM) that blocks interactions with PtdSer, CEACAM1, and Gal-9. This blockade enhances TNF-α and IFN-γ production in PBMCs, restoring T-cell-mediated anti-tumor activity, supporting its use in immuno-oncology research both in vitro and in vivo.

Research Area

Immunology & Inflammation

Images & Validation

Key Properties

CAS Number328540-44-9
MW596.6
Purity99.14%
FormulaC18H8Br2ClF3N4O2S
SMILESO=C(NC1=CC(Cl)=CC=C1O)C2=NN3C(N=C(C=C3C(F)(F)F)C=4SC=C(Br)C4)=C2Br
TargetImmunology/Inflammation related

Bioactivity

In Vivo
In a murine lung infection model, MG-T-19 (10 mg/kg, intranasal administration) significantly reduces bacterial burden in lung tissue, alleviates histopathological damage, and improves survival. MG-T-19 also enhances the efficacy of antibiotics like ceftazidime, showing synergistic antimicrobial effects.
In Vitro
MG-T-19 is a mannose-derived compound with antimicrobial activity. In vitro, MG-T-19 (2-16 μg/mL) effectively inhibits the growth of various Pseudomonas aeruginosa strains, including drug-resistant clinical isolates. MG-T-19 blocks bacterial adhesion to host cells and prevents biofilm formation across different human cell models.

Storage & Handling

Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

MGT-19, MG T19
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Key Properties

No computed properties available.

Documents Download

Datasheet
Product Information
Download

Request a Document

Protocol Information

MG-T-19 (orb2802249)

  • Star
  • Star
  • Star
  • Star
  • Star
  • 0.0
Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

Login to Submit a Review

No reviews yet

Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

(This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 240.00
5 mg
$ 530.00
10 mg
$ 740.00
25 mg
$ 1,120.00
50 mg
$ 1,530.00
100 mg
$ 2,010.00
200 mg
$ 2,730.00
DispatchUsually dispatched within 5-10 working days
Bulk Enquiry