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Millepachine

SKU: orb1303615

Description

Millepachine

Research Area

Cell Biology

Images & Validation

Key Properties

CAS Number1393922-01-4
MW350.41
Purity99.73%
FormulaC22H22O4
SMILESCOc1ccc(\C=C\C(=O)c2ccc(OC)c3C=CC(C)(C)Oc23)cc1
TargetApoptosis
SolubilityDMSO:100 mg/mL (285.38 mM);10% DMSO+90% Corn Oil:3.3 mg/mL (9.42 mM)

Bioactivity

Target IC50
Proliferation:4 μM(A2780CP cells)
In Vivo
Millepachine (20 mg/kg; i.v.) reduced tumor volume and weight with inhibitory rates of 73.21% and 65.58% in A2780S and A2780CP xenograft models, respectively, and does not induce acquired drug resistance in an excised A2780S xenograft model.
In Vitro
Millepachine (2-8 μM; 24 h) inhibits ATP-binding cassette transporter activity in A2780CP cells. Millepachine (2-8 μM; 24 or 48 h) induces significant G2/M arrest and apoptosis of cisplatin-sensitive A2780S and cisplatin-resistant A2780CP cells. The percentage of cells in the G2/M fraction increased from 15.99% in vehicle cells to 24.93%, 60.67%, and 77.31% at dose of 2, 4, and 8 μM in A2780S cells, respectively. Millepachine (2-8 μM; 24 h) decreases topoisomerase II levels in A2780S and A2780CP cells. Millepachine (1.25-20 μM; 48 h) remarkably inhibits the proliferation of cisplatin-resistant A2780CP cells with an IC50 of 4 μM.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Benth, chalcone, Chinese, cancer, bioactive, antitumor, Apoptosis, natural, Millepachine, Millettia, pachycarpa, inhibit, Inhibitor, herbal, medicine

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Key Properties

No computed properties available.

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Millepachine (orb1303615)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 90.00
5 mg
$ 160.00
1 ml x 10 mM (in DMSO)
$ 180.00
10 mg
$ 200.00
25 mg
$ 320.00
50 mg
$ 440.00
100 mg
$ 640.00
200 mg
$ 830.00
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