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Millepachine

SKU: orb1303615

Description

Millepachine

Research Area

Cell Biology

Images & Validation

Key Properties

CAS Number1393922-01-4
MW350.41
Purity99.28% (May vary between batches)
FormulaC22H22O4
SMILESCOc1ccc(\C=C\C(=O)c2ccc(OC)c3C=CC(C)(C)Oc23)cc1
TargetApoptosis
SolubilityDMSO:100 mg/mL (285.38 mM);10% DMSO+90% Corn Oil:3.3 mg/mL (9.42 mM)

Bioactivity

Target IC50
Proliferation:4 μM(A2780CP cells)
In Vivo
Millepachine (20 mg/kg; i.v.) reduced tumor volume and weight with inhibitory rates of 73.21% and 65.58% in A2780S and A2780CP xenograft models, respectively, and does not induce acquired drug resistance in an excised A2780S xenograft model.
In Vitro
Millepachine (2-8 μM; 24 h) inhibits ATP-binding cassette transporter activity in A2780CP cells. Millepachine (2-8 μM; 24 or 48 h) induces significant G2/M arrest and apoptosis of cisplatin-sensitive A2780S and cisplatin-resistant A2780CP cells. The percentage of cells in the G2/M fraction increased from 15.99% in vehicle cells to 24.93%, 60.67%, and 77.31% at dose of 2, 4, and 8 μM in A2780S cells, respectively. Millepachine (2-8 μM; 24 h) decreases topoisomerase II levels in A2780S and A2780CP cells. Millepachine (1.25-20 μM; 48 h) remarkably inhibits the proliferation of cisplatin-resistant A2780CP cells with an IC50 of 4 μM.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Benth, chalcone, Chinese, cancer, bioactive, antitumor, Apoptosis, natural, Millepachine, Millettia, pachycarpa, inhibit, Inhibitor, herbal, medicine

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Key Properties

No computed properties available.

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Millepachine (orb1303615)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 90.00
5 mg
$ 140.00
1 ml x 10 mM (in DMSO)
$ 160.00
10 mg
$ 200.00
25 mg
$ 320.00
50 mg
$ 440.00
100 mg
$ 640.00
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