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ML281

SKU: orb1223320

Description

ML-281 is a potent ans selective STK33 inhibitor (IC50 = 14 nM). ML281 showed low nanomolar inhibition of purified recombinant STK33 and a distinct selectivity profile as compared to other STK33 inhibitors. ML281 is a valuable addition to small-molecule probes of STK33. v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) is the most mutated oncogene, and KRAS mutations have been found in up to 20% of all human tumors. STK33 was selectively toxic to KRAS-dependent cancer cell lines, suggesting that small-molecule inhibitors of STK33 might selectively target KRAS-dependent cancers.

Images & Validation

Key Properties

CAS Number1404437-62-2
MW389.47
Purity>98% (HPLC)
FormulaC22H19N3O2S
SMILESO=C(c1cccs1)Nc1ccc(C(C)C)cc1c1nc2c(cccc2)[nH]c1=O
TargetSTK33
SolubilityDMSO : ≥ 30 mg/mL. 77.03 mM; H2O : < 0.1 mg/mL

Bioactivity

In Vitro
Cell Viability Assay Cell line: NCI-H446 cells. Concentration: 10 μM. Incubation time: 72 hours. Result: Suppressed cell viability of NCI-H446 cells.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

ML-281 | ML-281 | ML281

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  • ML281 [orb1304214]

    99.87% (May vary between batches)

    1404437-62-2

    389.47

    C22H19N3O2S

    5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 1 mg, 500 mg, 1 ml x 10 mM (in DMSO)
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ML281 (orb1223320)

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Available Sizes

Select a size below

2 mg
$ 100.00
5 mg
$ 140.00
10 mg
$ 170.00
25 mg
$ 320.00
50 mg
$ 540.00
100 mg
$ 780.00
200 mg
$ 1,110.00
500 mg
$ 1,660.00