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Mogroside IIe

SKU: orb1297580

Description

Mogroside IIe, a key bioactive cucurbitane glycoside from unripe Siraitia grosvenorii fruit, acts as an inhibitor of the IL-9/IL-9R signaling pathway. This compound is a valuable research tool for studying allergic inflammation and immune regulation in both cellular and animal models.

Research Area

Immunology & Inflammation

Images & Validation

Key Properties

CAS Number88901-38-6
MW801.01
Purity99.89%
FormulaC42H72O14
SMILES[H][C@@]1(CC[C@@]2(C)[C@]3([H])CC=C4[C@@]([H])(CC[C@H](O[C@]5([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O)C4(C)C)[C@]3(C)[C@H](O)C[C@]12C)[C@H](C)CC[C@@H](O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(C)(C)O
TargetIL Receptor
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (4.99 mM);DMSO:100 mg/mL (124.84 mM)

Bioactivity

In Vivo
Mogroside IIE treatment decreased the levels of serum lipase and serum amylase in mice injected with cerulein plus LPS without influencing inflammation significantly. A multi-cytokine array revealed that mogroside IIE decreased the level of interleukin 9 (IL-9) in AP mice.
In Vitro
Mogroside IIE decreased the activity of trypsin and cathepsin B induced by cerulein plus lipopolysaccharide (LPS) in the pancreatic acinar cell line AR42J and primary acinar cells in a dose- and time-dependent manner.

Storage & Handling

Storagekeep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Inhibitor, IL Receptor, inhibit, ILReceptor, IL-9, Mogroside IIe
Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

Mogroside IIe (orb1297580)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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1 mg
$ 100.00
5 mg
$ 180.00
10 mg
$ 240.00
1 ml x 10 mM (in DMSO)
$ 250.00
25 mg
$ 360.00
50 mg
$ 500.00
100 mg
$ 680.00
200 mg
$ 900.00
DispatchUsually dispatched within 3-5 working days
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