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MRL-871

SKU: orb1687422

Description

MRL-871 is a selective allosteric inhibitor of RORγt, reducing IL-17a mRNA in EL4 cells, and also acts as a partial PPARγ agonist. This small molecule is a valuable research tool for investigating Th17 cell biology and autoimmune disease mechanisms in both cellular and animal models.

Research Area

Metabolism Research

Images & Validation

Key Properties

CAS Number1392809-08-3
MW444.79
Purity99.66%
FormulaC22H12ClF3N2O3
SMILESO=C(O)C=1C=CC(=CC1)C2=NN(C(=O)C=3C(Cl)=CC=CC3C(F)(F)F)C=4C=CC=CC24
TargetROR
SolubilityDMSO:15 mg/mL (33.72 mM)

Bioactivity

Target IC50
RORγt:264 nM
In Vitro
MRL-871 is a reverse agonist of retinoic acid-associated orphan receptor γt (RORγt) with a high affinity, KD value of 250 nM and IC50 of 264 nM.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

MRL871
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Key Properties

No computed properties available.

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Protocol Information

MRL-871 (orb1687422)

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Available Sizes

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1 mg
$ 140.00
5 mg
$ 290.00
1 ml x 10 mM (in DMSO)
$ 320.00
10 mg
$ 460.00
25 mg
$ 880.00
50 mg
$ 1,320.00
100 mg
$ 2,030.00
200 mg
$ 2,720.00
DispatchUsually dispatched within 5-10 working days
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