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MRS8454

SKU: orb3173615

Description

MRS8454 is a positive allosteric modulator (PAM) of the A3 adenosine receptor (A3AR). It significantly enhances the maximal effect of the standard agonist Cl-IB-MECA to approximately 286%-300% and notably decreases its EC50 value. MRS8454 effectively augments the ability of A3AR agonists to inhibit forskolin-induced cAMP accumulation and can be utilized in the development of molecular probes.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

TargetAdenosine Receptor

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information