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MRT-81

SKU: orb1298036

Description

MRT-81 is a potent smoothened (SMO) receptor antagonist effective in both human and rodent systems, inhibiting Hedgehog signaling with an IC50 of 41 nM in Shh-Light2 cells. This compound is a valuable research tool for studying the Hedgehog pathway's role in cancer, applicable in both in vitro and in vivo experimental models.

Research Area

Pharmacology & Drug Discovery, Stem Cell & Developmental Biology

Images & Validation

Key Properties

CAS Number1263132-08-6
MW555.64
Purity99.72%
FormulaC31H29N3O5S
SMILESCOc1cc(cc(OC)c1OC)C(=O)NC(=S)Nc1ccc(C)c(NC(=O)c2ccc(cc2)-c2ccccc2)c1
TargetSmo,Hedgehog/Smoothened
Solubility10% DMSO+90% Corn Oil:2.5 mg/mL (4.5 mM);DMSO:50 mg/mL (89.99 mM)

Bioactivity

Target IC50
Smo receptor (Shh-light2 cells):41 nM (IC50)
In Vitro
MRT-81 inhibits the differentiation of the mesenchymal pluripotent C3H10T1/2 cells into alkaline phosphatase positive osteoblasts induced by the Smo agonist SAG with 0.1 μM, with an IC50 value of 64 nM.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Shh-light2 cells, rat granule cell precursors, Smoothened, smoothened, Smo, rodent, BODIPY-cyclopamine, C3H10T1/2 cells, human, Hedgehog, Inhibitor, MRT81, MRT 81, MRT-81, inhibit
Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

MRT-81 (orb1298036)

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% DMSO +
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% Tween 80 +
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Available Sizes

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1 mg
$ 90.00
5 mg
$ 140.00
1 ml x 10 mM (in DMSO)
$ 160.00
10 mg
$ 190.00
25 mg
$ 310.00
50 mg
$ 430.00
100 mg
$ 580.00
200 mg
$ 770.00
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