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Mutated EGFR-IN-1

SKU: orb1307999

Description

Mutated EGFR-IN-1, an analog of Osimertinib, serves as a key chemical intermediate for developing inhibitors targeting oncogenic EGFR mutants including L858R, exon 19 deletions, and the resistant T790M variant. It is utilized in preclinical research for both in vitro enzymatic assays and in vivo efficacy studies in relevant xenograft models.

Research Area

Cardiovascular Research, Signal Transduction

Images & Validation

Key Properties

CAS Number1421372-66-8
MW445.56
Purity99.73%
FormulaC25H31N7O
SMILESCOc1cc(N(C)CCN(C)C)c(N)cc1Nc1nccc(n1)-c1cn(C)c2ccccc12
TargetEGFR
SolubilityDMSO:7.5 mg/mL (16.83 mM)

Bioactivity

In Vitro
Mutated EGFR inhibitor acts as egfr modulators useful for treating cancer.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
DisclaimerFor research use only

Alternative Names

Mutated EGFRIN1, Mutated EGFR-IN-1, Mutated EGFR IN 1, inhibit, Osimertinib, Osimertinib analog, EGFR, EGFR (L858R), EGFR (T790M), EGFR(Exon 19 deletion/T790M), EGFRT790M, EGFRExon 19 deletion/T790M, EGFRL858R, Epidermal growth factor receptor, ErbB-1, Inhibitor, HER1

Similar Products

  • Mutated EGFR-IN-1 [orb1218838]

    >98% (HPLC)

    1421372-66-8

    445.6

    C25H31N7O

    50 mg, 100 mg, 200 mg, 1 g, 500 mg, 25 mg
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Key Properties

No computed properties available.

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Mutated EGFR-IN-1 (orb1307999)

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Available Sizes

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1 ml x 10 mM (in DMSO)
$ 90.00
25 mg
$ 100.00
50 mg
$ 110.00
100 mg
$ 130.00
200 mg
$ 160.00
500 mg
$ 240.00
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