N-Acetylcysteine ethyl ester

SKU: orb2279151

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Description

N-Acetyl-L-cysteine ethyl ester (NACET) is a cell-permeable cysteine derivative exhibiting antioxidant, anti-inflammatory, and pro-apoptotic activities. It is utilized in research areas including cancer biology and oxidative stress studies, with applications in both cellular and animal models to investigate its mechanisms of action.

Research Area

Cell Biology

Images & Validation

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Key Properties

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CAS Number	59587-09-6
MW	191.3
Purity	>95%
Formula	C₇H₁₃NO₃S
SMILES	CCOC(=O)[C@H](CS)NC(C)=O
Target	Antioxidant
Solubility	Soluble in DMSO (60 mg/ml)

Bioactivity

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In Vitro

Under concomitant oxidative stress induced by 2 mM H2O2, N-Acetyl-L-cysteine ethyl ester (NACET) showed strong and significant protective effect on RPE cells when the concentration was 0.4 mM. Moreover, NACET treatment also resulted in an enhanced protective effect when RPE cells were stressed by the organic ROS generator peroxide tert-Butyl hydroperoxide (t-BOOH).NACET significantly increased both intracellular GSH and cysteine at 0.2 and 1 mM concentrations, respectively, as well as extracellular total GSH.

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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NACET; NAC ethyl ester; (R)-Ethyl 2-acetamido-3-mercaptopropanoate

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Compound Identifiers

PubChem CID

148861 ↗

Key Properties

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No computed properties available.

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