N-Acetyl-L-cysteine ethyl ester

SKU: orb2279151

Description

N-Acetyl-L-cysteine ethyl ester (NACET) is a cell-permeable cysteine derivative exhibiting antioxidant, anti-inflammatory, and pro-apoptotic activities. It is utilized in research areas including cancer biology and oxidative stress studies, with applications in both cellular and animal models to investigate its mechanisms of action.

Research Area

Immunology & Inflammation, Metabolism Research, Signal Transduction

Images & Validation

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Key Properties

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CAS Number	59587-09-6
MW	191.25
Purity	99.15%
Formula	C₇H₁₃NO₃S
SMILES	CCOC(=O)[C@H](CS)NC(C)=O
Target	Antioxidant,Reactive Oxygen Species,ROS
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (5.23 mM);DMSO:45 mg/mL (235.29 mM);H2O:90 mg/mL (470.59 mM)

Bioactivity

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In Vitro

Under concomitant oxidative stress induced by 2 mM H2O2, N-Acetyl-L-cysteine ethyl ester (NACET) showed strong and significant protective effect on RPE cells when the concentration was 0.4 mM. Moreover, NACET treatment also resulted in an enhanced protective effect when RPE cells were stressed by the organic ROS generator peroxide tert-Butyl hydroperoxide (t-BOOH).NACET significantly increased both intracellular GSH and cysteine at 0.2 and 1 mM concentrations, respectively, as well as extracellular total GSH.

Storage & Handling

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Storage	store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Antioxidant, N-Acetylcysteine ethyl ester, NACET, N-Acetyl-L-cysteine ethyl ester

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Compound Identifiers

PubChem CID

148861 ↗

Key Properties

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No computed properties available.

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