N-Formyl-Met-Leu-Phe

SKU: orb1300082

Description

Research Area

Cell Biology

Images & Validation

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Key Properties

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CAS Number	59880-97-6
MW	437.55
Purity	98.00%
Formula	C₂₁H₃₁N₃O₅S
SMILES	CSCC[C@H](NC=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Target	TNF
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.54 mM);DMSO:120 mg/mL (274.25 mM)

Bioactivity

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In Vivo	N-Formyl-Met-Leu-Phe(fMLP) promoted bone formation in zebrafish and rabbits, suggesting its physiological relevance in vivo.
In Vitro	N-Formyl-Met-Leu-Phe receptor is associated with a Ni GTP regulatory protein, and N-Formyl-Met-Leu-Phe complex is important in the control of several neutrophil functions. Read more...
Animal Research	ebrafish (Danio rerio) embryos were collected from spontaneous spawnings reared at 28.5 ℃. Three days postfertilization (～1 day after hatching), feeding of the commercial powder for baby fish was started. Zebrafish embryos were stimulated with fMLP from 8 to 48 h postfertilization (hpf), washed, and raised at 28.5 ℃. At 5 days postfertilization (dpf), 20 zebrafish were stained with Alizarin Red for examination of the effect of fMLP on bone formation. Zebrafish were fixed in 4% paraformaldehyde for 12–18 h. Following fixation, fish were depigmented overnight in 1% KOH containing 3% H2O2 and immersed for 2 h in 0.5% KOH containing 0.05% Alizarin Red, pH 4.2. Alizarin-stained fish were then cleared again in 1% KOH and observed under a microscope. Read more...

Storage & Handling

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Storage	keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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fMLP, Inhibitor, inhibit, N Formyl Met Leu Phe, NFormylMetLeuPhe, N-Formyl-Met-Leu-Phe, N-Formyl-MLF, TNF Receptor, TNF, TNFR, Tumor Necrosis Factor Receptor

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Compound Identifiers

PubChem CID

443295 ↗

Key Properties

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No computed properties available.

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