Naltrexone hydrochloride

SKU: orb1225985

Description

A potent, competitive antagonist for μ, κ, δ, and σ-opioid receptors with Ki of 0.0825 nM, 0.509 nM, and 8.02 nM, for MOR, KOR, and DOR, respectively; also inhibits IL-6 and TNFα production in human immune cell subsets following stimulation with ligands for intracellular TLRs; a TLR-4 antognist that inhibits LPS-induced TLR4 downstream NO production in microglia BV-2 cells (IC50=105 uM).Alcoholism Approved.

Images & Validation

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Key Properties

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CAS Number	16676-29-2
MW	377.8618
Purity	>98% (HPLC)
Formula	C₂₀H₂₄ClNO₄
SMILES	C1CC1CN2CC[C@]34[C@@H]5C(=O)CC[C@]3([C@H]2CC6=C4C(=C(C=C6)O)O5)O.Cl
Target	Opioid Receptor
Solubility	DMSO: ≥ 33 mg/mL

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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NIH 8503

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Gene Symbol

Opioid Receptor

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