Naltrexone hydrochloride

SKU: orb1310125

Description

Naltrexone hydrochloride is a potent opioid receptor antagonist used to study addiction mechanisms and treatment. It is widely applied in preclinical research for investigating opioid and alcohol dependence, utilizing both in vitro binding assays and in vivo behavioral models.

Research Area

Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	16676-29-2
MW	377.862
Purity	>99.99% (May vary between batches)
Formula	C₂₀H₂₄ClNO₄
SMILES	Cl.Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O
Target	Opioid Receptor
Solubility	DMSO:62.5 mg/mL (165.4 mM);H2O:37.1 mM

Bioactivity

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Target IC50

Opioid receptor:8 nM

In Vivo

Naltrexone (0.32 mg/kg) reduces ethanol-reinforced responding at the concentration that maintained the most responding (1% or 2%) in rhesus monkeys. Naltrexone (0.1 mg/kg) reduces ethanol-reinforced responding, both at a low ethanol concentration (0.25%) that produced little ethanol intake (g/kg), and at a higher concentration (4%) with an appreciable intake. Naltrexone (1-3 mg/kg) potently and dose-dependently inhibits reinstatement of ethanol-seeking produced by non-contingent deliveries of the liquid dipper filled with 8% ethanol. Naltrexone elicits optimal enhancement of morphine's antinociceptive potency in mice when co-administered (i.p.) at about 100 ng/kg together with morphine (3 mg/kg). Naltrexone (10 ng/kg i.p.) augments the antinociception produced by an acute submaximal dose of intrathecal (5 mg) or systemic (7.5 mg/kg i.p.) morphine in the tail-flick test in rats. Naltrexone combined with Morphine inhibits the decline in morphine antinociception and prevented the loss of morphine potency in rats. Naltrexone significantly suppresses ethanol self-administration and prevents ethanol-induced increases in dialysate dopamine levels. Naltrexone completely prevents the reduction in anogenital distance in prenatally stressed (PS) males and restores the growth rate of both sexes. Naltrexone also decreases the anxiety of PS rats in the plus-maze, increases the opioid component of exploration to control levels, but increases anxiety in control males.

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Depade, Antaxone, Opioid Receptor, OpioidReceptor, Naltrexone HCl, Naltrexone Hydrochloride, Naltrexone hydrochloride, Trexan

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Compound Identifiers

PubChem CID

5485201 ↗

Key Properties

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No computed properties available.

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