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Navarixin

SKU: orb1300043

Description

Navarixin (MK-7123/SCH527123) is a selective CXCR2 antagonist that blocks neutrophil activation and migration. It is a research tool for studying neutrophilic inflammation in models of pulmonary diseases such as COPD and asthma, with demonstrated effects in both in vitro and in vivo experimental systems.

Research Area

Cell Biology, Immunology & Inflammation, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number473727-83-2
MW397.42
Purity99.51% (May vary between batches)
FormulaC21H23N3O5
SMILESCC[C@@H](Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)c1ccc(C)o1
TargetCXCR
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.03 mM);DMSO:55 mg/mL (138.39 mM)

Bioactivity

Target IC50
CXCR2 (mouse):0.2 nM (Kd)|[125I]-CXCL8-CXCR2:0.97 nM (IC50)|CXCR1 (cynomolgus):41 nM (Kd)|CXCR2 (rat):0.2 nM (Kd)|CXCR2 (cynomolgus):0.08 nM (Kd)|[125I]-CXCL8-CXCR1:43 nM (IC50)
In Vitro
Navarixin is a potent, allosteric antagonist of both CXCR1 and CXCR2, with Kd values of 41 nM for cynomolgus CXCR1 and 0.20 nM, 0.20 nM, and 0.08 nM for mouse, rat, and cynomolgus monkey CXCR2, respectively .

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

SCH 527123, SCH527123, SCH-527123, CXC chemokine receptors, CXCR2, CXCR1, CXCR, Inhibitor, inhibit, MK 7123, MK7123, MK-7123, Navarixin

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Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

Navarixin (orb1300043)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 80.00
5 mg
$ 120.00
1 ml x 10 mM (in DMSO)
$ 130.00
10 mg
$ 170.00
25 mg
$ 270.00
50 mg
$ 380.00
100 mg
$ 540.00
500 mg
$ 1,120.00
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