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SCH-527123

SKU: orb1225006

Description

A potent, selective, orally bioavailable CXCR2/CXCR1 receptor antagonist with Kd of 0.08 and 41 nM for cynomolgus CXCR2 and CXCR1, respectively; potently inhibits CXCR2-mediated chemotaxis with IC50 of 3-6 nM; inhibits neutrophil recruitment, mucus production, and goblet cell hyperplasia in animal models of pulmonary inflammation.COPD Phase 2 Discontinued.

Images & Validation

Key Properties

CAS Number473727-83-2
MW397.4244
Purity>98% (HPLC)
FormulaC21H23N3O5
SMILESO=C(N(C)C)C1=CC=CC(NC2=C(N[C@@H](C3=CC=C(C)O3)CC)C(C2=O)=O)=C1O
TargetChemokine Receptor
Solubility10 mM in DMSO

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

SCH527123 | Navarixin | SCH 527123 | MK-7123

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Protocol Information

SCH-527123 (orb1225006)

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Available Sizes

Select a size below

5 mg
$ 150.00
10 mg
$ 200.00
25 mg
$ 340.00
50 mg
$ 540.00
100 mg
$ 790.00
500 mg
$ 1,710.00