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NBD-556

SKU: orb1307977

Description

NBD-556 is a small-molecule CD4 mimetic that binds to HIV-1 gp120 and induces conformational changes similar to those triggered by CD4. It serves as a valuable research tool for studying viral entry mechanisms and for the in vitro evaluation of entry inhibitors in HIV/AIDS research.

Research Area

Infectious Disease & Virology, Protein Biochemistry

Images & Validation

Key Properties

CAS Number333353-44-9
MW337.84
Purity99.79% (May vary between batches)
FormulaC17H24ClN3O2
SMILESCC1(C)CC(CC(C)(C)N1)NC(=O)C(=O)Nc1ccc(Cl)cc1
TargetHIV Protease
Solubility10% DMSO+90% Corn Oil:2 mg/mL (5.92 mM);DMSO:33.33 mg/mL (98.66 mM);H2O:< 0.1 mg/mL (insoluble)

Bioactivity

In Vitro
HIV NBD-556 N-phenyl-N′-(2,2,6,6-tetramethyl-piperidin-4-yl)-oxalamide analogs as a novel class of human immunodeficiency virus type 1 (HIV-1) entry inhibitors that block the gp120–CD4 interaction. The small molecule NBD-556 mimics CD4 by binding the gp120 exterior envelope glycoprotein, moderately inhibiting virus entry into CD4-expressing target cells, and enhancing CCR5 binding and virus entry into CCR5-expressing cells lacking CD4.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

virus-cell, Inhibitor, HIV-1, HIVProtease, HIV, HIV Protease, fusion, gp120, Human immunodeficiency virus, inhibit, NBD 556, NBD556, NBD-556, mimetic, CD4
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Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

NBD-556 (orb1307977)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

5 mg
$ 70.00
1 ml x 10 mM (in DMSO)
$ 80.00
10 mg
$ 90.00
25 mg
$ 140.00
50 mg
$ 190.00
100 mg
$ 260.00
200 mg
$ 360.00
DispatchUsually dispatched within 3-5 working days
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