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Necroptosis-IN-3

SKU: orb1685697

Description

Necroptosis-IN-3 (STX1638) is a dual-function small molecule that acts as an inhibitor of TNF-α-induced necroptosis and the enzyme 11β-HSD1. This compound is a valuable research tool for investigating programmed cell death pathways and metabolic regulation in both cellular and animal models of inflammatory and metabolic diseases.

Research Area

Cell Biology, Metabolism Research

Images & Validation

Key Properties

CAS Number547698-18-0
MW223.33
Purity99.85% (May vary between batches)
FormulaC12H17NOS
SMILESC(NCC1=CC=CS1)(=O)C2CCCCC2
TargetDehydrogenase,Necroptosis
SolubilityDMSO:55 mg/mL (246.27 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (8.96 mM)

Bioactivity

In Vitro
TNF-α-IN-8 (Compound 69) (0.030-100 μM; 24 h) inhibits TNF-α-induced necrosis in FADD-deficient human Jurkat T cells .

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Cyclohexanecarboxamide, N-(2-thienylmethyl)-, Necroptosis, Necroptosis-IN-3

Similar Products

  • Necroptosis-IN-3 [orb2900739]

    >98% (HPLC)

    547698-18-0

    223.33

    C12H17NOS

    1 g, 500 mg, 50 mg, 100 mg, 200 mg, 5 mg, 10 mg, 25 mg
Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

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Necroptosis-IN-3 (orb1685697)

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(Recommended: An additional animal making an allowance for loss during the experiment)

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% DMSO +
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% Tween 80 +
%

Available Sizes

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1 ml x 10 mM (in DMSO)
$ 70.00
25 mg
$ 90.00
50 mg
$ 120.00
100 mg
$ 160.00
200 mg
$ 230.00
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