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Necroptosis-IN-3

SKU: orb2900739

Description

Necroptosis-IN-3 (Compound 69) is a necroptosis inhibitor that inhibits TNF-α induced necroptosis. Necroptosis-IN-3 (Compound STX1638) also inhibits 11β-HSD1.

Images & Validation

Key Properties

CAS Number547698-18-0
MW223.33
Purity>98% (HPLC)
FormulaC12H17NOS
SMILESC(NCC1=CC=CS1)(=O)C2CCCCC2
SolubilityIn Vitro: DMSO : 100 mg/mL (447.77 mM; Ultrasonic )

Bioactivity

In Vitro
Cell Viability Assay Cell line: Fadd-/- Jurkat and L929 cells, treated with 10 ng/mL of human TNF-α. Concentration: 0.030-100 μM Incubation time: 24 h. Result: Showed necroptosis inhibitory activity with an ED50 of 7.724 μM for Fadd-/- Jurkat cells and was inactive for L929 cells.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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    547698-18-0

    223.33

    C12H17NOS

    25 mg, 50 mg, 100 mg, 1 ml x 10 mM (in DMSO), 200 mg
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Protocol Information

Necroptosis-IN-3 (orb2900739)

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Available Sizes

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500 mg
5 mg
$ 100.00
10 mg
$ 150.00
25 mg
$ 270.00
50 mg
$ 390.00
100 mg
$ 540.00
200 mg
$ 740.00