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Necrostatin-5

SKU: orb1692789

Description

Necrostatin-5 (Nec-5) is a potent and selective RIP1 kinase inhibitor that blocks necroptotic cell death. It exhibits an EC50 of 240 nM in preventing TNF-α-induced necrosis in FADD-deficient Jurkat cells. This small molecule is a valuable research tool for investigating necroptosis in cellular models and related disease pathways.

Research Area

Cell Biology, Signal Transduction

Images & Validation

Key Properties

CAS Number337349-54-9
MW383.49
Purity98.03%
FormulaC19H17N3O2S2
SMILESO=C1C=2C3=C(SC2N=C(SCC#N)N1C4=CC=C(OC)C=C4)CCCC3
TargetRIP kinase,Necroptosis
SolubilityDMSO:4.5 mg/mL (11.73 mM)

Bioactivity

Target IC50
Cell necroptosis:240 nM (EC50)

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Nec-5, necroptosis, Necrostatin-5, RIPkinase, RIP kinase, RIP1
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Key Properties

No computed properties available.

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Protocol Information

Necrostatin-5 (orb1692789)

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10 mg
$ 80.00
25 mg
$ 130.00