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Nelociguat

SKU: orb1299984

Description

Nelociguat (BAY60-4552) is a stimulator of soluble guanylate cyclase (sGC), a central enzyme in nitric oxide (NO) signaling. This research compound is used in vitro and in vivo to study cardiovascular and pulmonary diseases, including pulmonary hypertension, by potentiating the NO-sGC-cGMP pathway.

Research Area

Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number625115-52-8
MW408.39
Purity99.19%
FormulaC19H17FN8O2
SMILESCOC(=O)Nc1c(N)nc(nc1N)-c1nn(Cc2ccccc2F)c2ncccc12
TargetGuanylate cyclase
SolubilityDMSO:4.09 mg/mL (10.01 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.45 mM)

Bioactivity

In Vivo
Bilateral CN crush injury followed by a 3-wk recovery period decreased erectile responses to ES CN by about 50%. In CN-crushed rats, IV vardenafil 0.03 mg/kg and BAY 60-4552 (0.03 or 0.3 mg/kg) increased erectile responses to ES CN to the same extent: intracavernosal pressure/mean arterial pressure (ICP/MAP) at 10 Hz ES CN was 21±1% after vehicle, 25±3% (p<0.001) after vardenafil, and 26±5% and 27±5% after BAY 60-4552 0.03 mg/kg (p<0.01) and 0.3 mg/kg (p<0.001), respectively. The combination of vardenafil with BAY 60-4552 in CN-crushed rats totally restored erectile responses to ES CN equivalent to sham rats (ICP/MAP at 10 Hz ES CN: 34±4% after BAY 60-4552/vardenafil combination vs 39±4% in sham rats; not significant).
Animal Research
The acute effects of intravenous (IV) injection of vehicle, vardenafil 0.03 mg/kg, BAY 60-4552 0.03 mg/kg or 0.3 mg/kg, or a BAY 60-4552 0.03 mg/kg plus vardenafil 0.03 mg/kg combination were evaluated in CN-crushed rats.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Guanylate cyclase, Guanylatecyclase, Guanylate Cyclase, Inhibitor, inhibit, Nelociguat, BAY60-4552

Similar Products

  • Nelociguat [orb1220488]

    >98% (HPLC)

    625115-52-8

    408.39

    C19H17FN8O2

    100 mg, 200 mg, 5 mg, 2 mg, 500 mg, 1 g, 10 mg, 25 mg, 50 mg
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Key Properties

No computed properties available.

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Protocol Information

Nelociguat (orb1299984)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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1 ml x 10 mM (in DMSO)
$ 70.00
10 mg
$ 80.00
25 mg
$ 100.00
50 mg
$ 120.00
100 mg
$ 160.00
500 mg
$ 320.00
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