Nevadensin

SKU: orb1301552

Description

Nevadensin is a natural small molecule that inhibits the bioactivation of estragole and demonstrates protective effects against methyleugenol-induced hepatocarcinogenicity markers in vivo. It also exhibits antimycobacterial activity in vitro, with research applications in toxicology and infectious disease studies.

Research Area

Cell Biology, Infectious Disease & Virology, Metabolism Research, Molecular Biology

Images & Validation

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Key Properties

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CAS Number	10176-66-6
MW	344.32
Purity	99.91% (May vary between batches)
Formula	C₁₈H₁₆O₇
SMILES	O(C)C1=C2C(=C(O)C(OC)=C1O)C(=O)C=C(O2)C3=CC=C(OC)C=C3
Target	Apoptosis,DNA/RNA Synthesis,Antibacterial,Lipid,Anti-infection
Solubility	DMSO:14.71 mg/mL (42.72 mM)

Bioactivity

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Target IC50

CE1 (human):2.64 μM (IC50)|CE2 (human):132.8 μM (IC50)

In Vitro

The alkenylbenzene methyleugenol occurs naturally in a variety of spices and herbs, including basil, and their essential oils. At high dose levels methyleugenol induces hepatocarcinogenicity in rodents following bioactivation to 1'-sulfooxymethyleugenol which forms DNA adducts. METHODS AND RESULTS: This study investigated whether the inhibitory effect of the basil flavonoid Nevadensin on sulfotransferase (SULT)-mediated bioactivation of methyleugenol observed in vitro would also be reflected in a reduction of DNA adduct formation and a reduction in an early marker for liver carcinogenesis in an 8-week rat study. Co-exposure to methyleugenol and Nevadensin orally resulted in a significant inhibition of liver methyleugenol DNA adduct formation and in inhibition of hepatocellular altered foci induction, representing indicators for initiation of neoplasia. CONCLUSIONS: These results suggest that tumor formation could be lower in rodent bioassays when methyleugenol would be dosed in a matrix containing SULT inhibitors such as Nevadensin compared to experiments using the pure methyleugenol.

Storage & Handling

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Storage	keep away from direct sunlight \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Bacterial, Anti-infection, Antiinfection, Antifection, inhibit, inhibition, Nevadensin, natural, Pedunculin, Inhibitor, flavonoid, effect, selective, pharmacological

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Compound Identifiers

PubChem CID

160921 ↗

Key Properties

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No computed properties available.

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Nevadensin (orb1301552)

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Purity:	>99.99% (May vary between batches)
CAS Number:	152743-19-6
MW:	344.30
Formula:	C₁₈H₁₆O₇

Purity:	>98% (HPLC)
CAS Number:	10176-66-6
MW:	344.32
Formula:	C??H??O?

Nevadensin

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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