Nevanimibe hydrochloride

SKU: orb1309337

Description

Nevanimibe hydrochloride (PD-132301 hydrochloride) is a potent and selective ACAT1 inhibitor with an EC50 of 9 nM, suitable for oral administration. This small molecule is a valuable research tool for investigating cholesterol metabolism and atherosclerosis in both cellular and animal models.

Research Area

Cell Biology, Metabolism Research

Images & Validation

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Key Properties

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CAS Number	133825-81-7
MW	458.08
Purity	99.75% (May vary between batches)
Formula	C₂₇H₄₀ClN₃O
SMILES	Cl.CC(C)c1cccc(C(C)C)c1NC(=O)NCC1(CCCC1)c1ccc(cc1)N(C)C
Target	Acyltransferase,Apoptosis
Solubility	DMSO:41.67 mg/mL (90.97 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.37 mM)

Bioactivity

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Target IC50

ACAT1:EC50 of 9 nM|ACAT2:368 nM (EC50)

In Vitro

In H295R human adrenocortical carcinoma cells, Nevanimibe hydrochloride(ATR-101 hydrochloride) decreases the formation of cholesteryl esters and increases FC levels, demonstrating potent inhibition of ACAT1 activity. Caspase-3/7 levels and terminal deoxynucleotidyl transferase 2'-deoxyuridine 5'-triphosphate nick end labeled-positive cells are increased by ATR-101 treatment, indicating activation of apoptosis.

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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mono- acylglycerol acyltransferase, Inhibitor, inhibit, PD132301, PD-132301, PD132301 Hydrochloride, PD-132301 Hydrochloride, PD-132301 hydrochloride, PD 132301, PD 132301 Hydrochloride, Nevanimibe, Nevanimibe hydrochloride, Nevanimibe Hydrochloride, orally, O-acyltransferase, acyl-coenzyme, acyl-CoA:cholesterol acyltransferase, Acyltransferase, ACAT-1, A:cholesterol, adrenocortical, active, ATR101, ATR-101, ATR101 Hydrochloride, ATR101 hydrochloride, ATR-101 Hydrochloride, ATR 101, ATR 101 Hydrochloride, Apoptosis, cancer, Diglyceride acyltransferase, Diacylglycerol acyltransferase

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Compound Identifiers

PubChem CID

131678 ↗

Key Properties

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No computed properties available.

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