NFAT Transcription Factor Regulator-1

SKU: orb1709025

Description

Research Area

Immunology & Inflammation

Images & Validation

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Key Properties

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CAS Number	245747-71-1
MW	416.28
Purity	99.90%
Formula	C₁₇H₁₀F₆N₄O₂
SMILES	FC(F)Oc1cc(nn1-c1ccc(NC(=O)c2ccncc2F)cc1)C(F)(F)F
Target	Interleukin,IL Receptor
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (12.01 mM);DMSO:50 mg/mL (120.11 mM)

Bioactivity

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Target IC50	IL-2 synthesis:182 nM
In Vivo	NFAT Transcription Factor Regulator-1 demonstrates an inhibitory potency on T-cell IL-2 production that is approximately 10 times greater than cyclosporine, requiring doses of 3.0 mg/kg and 30 mg/kg, respectively, for comparable effects. In vivo studies in monkeys further reveal the potential of NFAT Transcription Factor Regulator-1 to block T-cell cytokine production effectively, suggesting its viability as a transplantation aid comparable to cyclosporine. Read more...
In Vitro	NFAT Transcription Factor Regulator-1 inhibits IL-2 synthesis(IC50 of 182 nM). NFAT Transcription Factor Regulator-1 inhibits human and rat PBMC proliferation with IC50s of 82 and 146 nM, respectively. NFAT Transcription Factor Regulator-1 is able to inhibit IL-4 and IL-5 production in human T-cell lines with similar potency to its effects on IL-2 release. Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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ILReceptor, IL-2 synthesis, IL-2, IL Receptor, NFAT Transcription Factor Regulator 1, NFAT Transcription Factor Regulator1, NFAT Transcription Factor Regulator-1

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Compound Identifiers

PubChem CID

9931706 ↗

Key Properties

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No computed properties available.

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