Nicotinamide riboside

SKU: orb1219709

Description

Nicotinamide riboside increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-induced metabolic abnormalities.Nicotinamide riboside (NR) supplementation in mammalian cells and mouse tissues increases NAD(+) levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high-fat diet-induced metabolic abnormalities.The natural vitamin Nicotinamide riboside (NR) could be used as a nutritional supplement to ameliorate metabolic and age-related disorders characterized by defective mitochondrial function.

Research Area

Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	1341-23-7
MW	255.25
Purity	>98% (HPLC)
Formula	C₁₁H₁₅N₂O₅
SMILES	NC(=O)c1ccc[n+](c1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Target	Sirtuin

Bioactivity

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In Vivo

Chronic Nicotinamide riboside (p.o. ; 400 mg/kg/day; for 16 weeks) supplementation increases plasma and intracellular NAD+ content in a tissue-specific manner. Animal model: 10-week-old C57Bl/6J mice. Dosage: 400 mg/kg. Administration: p.o. ; daily; for 16 weeks. Result: Increased plasma and intracellular NAD+ content in a tissue-specific manner.

In Vitro

Nicotinamide riboside (0.5 nM; 24 hours) reduces the acetylation status of Ndufa9 and SOD2.Nicotinamide riboside increases intracellular and mitochondrial NAD+ content in C2C12, Hepa1.6, and HEK293 cells in a concentration-dependent manner at concentrations ranging from 1-1000 μM. Nicotinamide riboside boosts NAD to restore antiviral poly(ADP-ribose) polymerase (PARP) functions to support innate immunity for coronavirus (CoVs), a cause of COVID-19. Western blot analysis. Cell line: HEK293T cells. Concentration: 0.5 nM Incubation time: 24 hours. Result: Reduced the acetylation status of Ndufa9 and SOD2.

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Gene Symbol

Sirtuin

Protocol Information

Find More Protocols

Applications:	WB
Reactivity:	Human
Species/Host:	Rabbit
Clonality:	Polyclonal
Conjugation:	Unconjugated

Applications:	FC, WB
Reactivity:	Human, Mouse
Species/Host:	Rabbit
Clonality:	Polyclonal
Conjugation:	Unconjugated

Applications:	IHC-P, WB
Predicted Reactivity:	Mouse
Reactivity:	Human
Species/Host:	Rabbit
Clonality:	Polyclonal
Conjugation:	Unconjugated

Applications:	ELISA, IHC, WB
Reactivity:	Human
Species/Host:	Rabbit
Clonality:	Polyclonal
Conjugation:	Unconjugated

Applications:	IHC, WB
Reactivity:	Human
Species/Host:	Rabbit
Clonality:	Polyclonal
Conjugation:	Unconjugated

Nicotinamide riboside

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

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