Nidanilimab Antibody

SKU: orb1980571

Description

Nidanilimab (CAN04) is a fully humanized anti-IL1RAP monoclonal antibody with high affinity (Kd 1.10 pM). It blocks IL-1α/β signaling to exert antitumor effects and is utilized in research for solid tumors like NSCLC and PDAC, with studies demonstrating activity in both in vitro and in vivo models.

Research Area

Immunology & Inflammation

Images & Validation

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Key Properties

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CAS Number	2171061-85-9
MW	150 kDa
Purity	> 95%
Target	Interleukin,IL Receptor

Bioactivity

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Target IC50	MC38 colon cancer cells (mouse):1 nM(EC50)
In Vivo	In nude C57Bl/6 mice, Nidanilimab (CAN04; 10 mg/kg; intraperitoneal injection) enhances the efficacy of two commonly used platinum-based chemotherapy drugs, cisplatin with gemcitabine and carboplatin with gemcitabine. Read more...
In Vitro	Nidanilimab (CAN04; 20 µg/mL) exhibits antibody-dependent cell-mediated cytotoxicity (ADCC) with glycoengineering-enhanced properties in mouse MC38 colon cancer cells, with an EC50 of less than 1 nM. Nidanilimab (20 µg/mL) blocks the IL1α and IL1β signaling pathways in mouse MC38 colon cancer cells, with IC50 values of 3.9 nM and 4.1 nM, respectively. Read more...

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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CAN 04, CAN04, CAN-04, IL-1, IL Receptor, ILReceptor, Nadunolimab, Nidanilimab

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Gene Symbol

Interleukin,IL Receptor

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