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Nirmatrelvir

SKU: orb1298161

Description

Nirmatrelvir (PF-07321332) is a potent, orally bioavailable inhibitor of the SARS-CoV-2 3CL protease (3CLpro). It is widely used in both in vitro biochemical assays and in vivo animal models to study antiviral mechanisms and therapeutic potential against COVID-19.

Research Area

Infectious Disease & Virology

Images & Validation

Key Properties

CAS Number2628280-40-8
MW499.53
Purity98.66%
FormulaC23H32F3N5O4
SMILESC(N[C@@H](C[C@H]1C(=O)NCC1)C#N)(=O)[C@@H]2[C@@]3([C@@](C3(C)C)(CN2C([C@@H](NC(C(F)(F)F)=O)[C@](C)(C)C)=O)[H])[H]
TargetSARS-CoV
SolubilityDMSO:257.5 mg/mL (515.48 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:13 mg/mL (26.02 mM)

Bioactivity

Target IC50
Vero C1008 cells:75 nM (EC50)|MRC5 cells:0.212 μM (EC50)
In Vivo
METHODS: To assay in vivo antiviral activity, Nirmatrelvir (20 mg/kg, 2% DMSO + 20% sulfobutylether-β-cyclodextrin in 0.9% saline) and Molnupiravir (20 mg/kg) were orally administered to SARS-CoV-2 infected K18-hACE2 transgenic mice twice daily for five days. RESULTS: In lethally infected mice, the combination of Nirmatrelvir and Molnupiravir demonstrated severe inhibition of SARS-CoV-2 replication in the lungs and brain and synergistically improved survival by up to 80%. 36% survival was achieved with Nirmatrelvir alone, and 43% with Molnupiravir alone.
In Vitro
PF-07321332 is a promising oral antiviral clinical candidate with well-established anti-SARS-CoV-2 activity in vitro.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

3CLpro, 3CLPRO, Antiviral, Inhibitor, HIV, inhibit, Nirmatrelvir, PF 07321332, PF-07321332, PF07321332, SARS coronavirus, SARSCoV, SARS-CoV, virus

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Key Properties

No computed properties available.

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Protocol Information

Nirmatrelvir (orb1298161)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 100.00
2 mg
$ 120.00
5 mg
$ 170.00
1 ml x 10 mM (in DMSO)
$ 180.00
10 mg
$ 240.00
25 mg
$ 390.00
50 mg
$ 580.00
100 mg
$ 740.00
200 mg
$ 1,040.00
500 mg
$ 1,530.00
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