Nitroflurbiprofen

SKU: orb1307960

Description

Nitroflurbiprofen is a nitric oxide (NO)-donating cyclooxygenase (COX) inhibitor. It is a research compound used to study vascular dysfunction, particularly for investigating the reduction of elevated intrahepatic vascular resistance in preclinical models of portal hypertension and cirrhosis.

Research Area

Immunology & Inflammation, Neuroscience

Images & Validation

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Key Properties

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CAS Number	158836-71-6
MW	361.36
Purity	99.88%
Formula	C₁₉H₂₀FNO₅
SMILES	CC(C(=O)OCCCCO[N+]([O-])=O)c1ccc(c(F)c1)-c1ccccc1
Target	COX
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (13.84 mM);DMSO:55 mg/mL (152.2 mM)

Bioactivity

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In Vivo	Nitroflurbiprofen (45 mg/kg; i.p.) improves portal hypertension without major adverse effects in thioacetamide-induced cirrhotic rats by attenuating intrahepatic vascular resistance, endothelial dysfunction, and hepatic hyperreactivity to vasoconstrictors. Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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COX, Cyclooxygenase, inhibit, Nitroxybutyl flurbiprofen, Nitroflurbiprofen, NO-flurbiprofen, Inhibitor, HCT1206, HCT-1206, HCT 1206

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Compound Identifiers

PubChem CID

119387 ↗

Key Properties

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No computed properties available.

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