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NMI 8739

SKU: orb1309747

Description

NMI 8739 is a D2 autoreceptor agonist that inhibits nitric oxide production and suppresses the release of pro-inflammatory cytokines CCL-20, MCP-1, and IL-6 in a concentration-dependent manner. This compound is a useful research tool for studying neuroinflammation and dopaminergic signaling in both cellular and animal models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number129024-87-9
MW463.65
Purity98.51% (May vary between batches)
FormulaC30H41NO3
SMILESCC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(=O)NCCc1ccc(O)c(O)c1
TargetDopamine Receptor
SolubilityEthanol:90 mg/mL (194.11 mM);DMSO:90 mg/mL (194.11 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.12 mM)

Bioactivity

In Vitro
NMI 8739 (2 μM) significantly inhibits IL-6 and CCL-20 release up to 49% and 37%, respectivel. NMI 8739 suppresses the production of PGE2 in a concentration-dependent manner with 25.3%, 75% reduction at doses of 100 nM and 1 μM, respectively.

Storage & Handling

StoragePure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

D2 receptor, DopamineReceptor, Dopamine Receptor, Dha-DA conjugate, n-docosahexaenoyl dopamine, NMI 8739, NMI8739, NMI-8739
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Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

NMI 8739 (orb1309747)

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% DMSO +
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% Tween 80 +
%

Available Sizes

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1 mg
$ 80.00
5 mg
$ 120.00
1 ml x 10 mM (in DMSO)
$ 130.00
10 mg
$ 170.00
25 mg
$ 260.00
50 mg
$ 360.00
100 mg
$ 520.00
200 mg
$ 730.00
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