N,N'-Diacetyl-L-cystine

SKU: orb1940707

Description

N,N'-Diacetyl-L-cystine is the disulphide dimer of N-acetylcysteine with immunomodulating properties. N,N'-diacetyl-L-cystine also has antiatherosclerotic effects in Watanabe-heritable hyperlipidemic rabbit (WHHL) rabbits. N,N'-diacetyl-L-cystine is also an effective and orally active modulator of contact sensitivity/delayed-type hypersensitivity reactions in rodents.(In Vivo):N,N'-Diacetyl-L-cystine (DiNAC; 0-973.11 μg/kg; p.o.; daily; for 12 weeks; WHHL rabbits) treatment decreases by 50% thoracic aorta atherosclerosis. However, it has no affecting plasma lipid levels.

Images & Validation

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Key Properties

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CAS Number	5545-17-5
MW	324.37
Purity	>98% (HPLC)
Formula	C₁₀H₁₆N₂O₆S₂
SMILES	O=C(O)[C@H](CSSC[C@@H](C(O)=O)NC(C)=O)NC(C)=O
Target	CDK4/CyclinD1\| CDK6/CyclinD3
Solubility	In Vitro: DMSO : 125 mg/mL (385.36 mM)

Bioactivity

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In Vivo

N, N'-Diacetyl-L-cystine (DiNAC; 0-973.11 μg/kg; oral administration; daily; for 12 weeks; WHHL rabbits) treatment reduces by 50% thoracic aorta atherosclerosis, without affecting plasma lipid levels. Animal model: Male heritable hyperlipidemic rabbit (WHHL) rabbits (10-22 weeks). Dosage: 0 μg/kg, 9.73 μg/kg, or 973.11 μg/kg. Administration: Oral administration; daily; for 12 weeks. Result: Reduced by 50% thoracic aorta atherosclerosis, without affecting plasma lipid levels.

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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DiNAC

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Gene Symbol

CDK4/CyclinD1| CDK6/CyclinD3

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