nordihydroguaiareticacid

SKU: orb1222164

Description

INSM-18, also known as nordihydroguaiaretic acid, NDGA and masoprocol, is a naturally occurring antioxidant dicatechol originally derived from the creosote bush Larrea divaricatta with antipromoter, anti-inflammatory, and antineoplastic activities. NDGA directly inhibits activation of two receptor tyrosine kinases (RTKs), the insulin-like growth factor receptor (IGF-1R) and the c-erbB2/HER2/neu receptor, resulting in decreased proliferation of susceptible tumor cell populations.

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Key Properties

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CAS Number	500-38-9
MW	302.37
Purity	>98% (HPLC)
Formula	C₁₈H₂₂O₄
SMILES	CC(CC1=CC(=C(C=C1)O)O)C(C)CC2=CC(=C(C=C2)O)O
Target	Antioxidant
Solubility	DMSO : 75 mg/mL 248.05 mM;

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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INSM18 | INSM-18, INSM 18, masoprocol

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Gene Symbol

Antioxidant

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