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NT-0249

SKU: orb2664685

Description

NT-0249 is a potent, orally bioavailable NLRP3 inflammasome inhibitor. It demonstrates anti-inflammatory effects in research models, reversing obesity, systemic inflammation, and astrocyte hyperplasia induced by a high-fat diet. This small molecule is a valuable tool for studying NLRP3-driven pathologies in metabolic and neuroinflammatory research.

Research Area

Immunology & Inflammation, Signal Transduction

Images & Validation

Key Properties

CAS Number2763617-39-4
MW481.54
Purity98.11%
FormulaC22H28N5NaO4S
SMILES[N-](C(NS(N(C[C@@H]1CCCO1)C2=CN(C)N=C2)(=O)=O)=O)C3=C4C(=CC5=C3CCC5)CCC4.[Na+]
TargetNOD,NOD-like Receptor (NLR)

Bioactivity

In Vivo
Two structurally distinct NLRP3 inhibitors, NT-0249 and NT-0796, were able to reverse obesity in a mouse model of diet-induced obesity (DIO), and DIO-driven hypothalamic glial fibrillary acidic protein (GFAP) expression could be blocked by administration of NT-0249 or NT-0796.

Storage & Handling

Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

NLRP3, NT0249

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Key Properties

No computed properties available.

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NT-0249 (orb2664685)

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Available Sizes

Select a size below

1 mg
$ 240.00
5 mg
$ 530.00
10 mg
$ 740.00
25 mg
$ 1,120.00
50 mg
$ 1,530.00
100 mg
$ 2,010.00
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